Cevimeline hydrochloride
Cat. No.：YN321291
| 产品名称: | Cevimeline hydrochloride |
| CAS No.: | 107220-28-0 |
| Chemical Name: | (2’R,3R)-rel-2’-methyl-spiro[1-azabicyclo[2.2.2]octane-3,5’-[1,3]oxathiolane], monohydrochloride |
| Synonyms: | 盐酸西维美林; AF102B hydrochloride |
| 分子量: | 235.77 |
| 分子式: | C₁₀H₁₈ClNOS |
| SMILES: | C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cevimeline hydrochloride (AF102B hydrochloride) 是一种乙酰胆碱的奎尼丁衍生物，也是一种选择性的和口服活性的毒蕈碱型M1和M3受体激动剂。Cevimeline hydrochloride 可刺激唾液腺分泌，并可用作口干症的一种催涎剂。Cevimeline hydrochloride 可穿过血脑屏障。 |
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Heinrich, J.N., Butera, J.A., Carrick, T., et al.Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonistsEur. J. Pharmacol.605(1-3),53-56(2009)
Kahn, S.T., and Johnstone, P.A.Management of xerostomia related to radiotherapy for head and neck cancerOncology (Williston Park)19(14),1827-1832(2005)
Ramos-Casals, M., Tzioufas, A.G., Stone, J.H., et al.Treatment of primary Sjögren syndrome: A systematic reviewJAMA304(4),452-460(2010)
