Diphenidol hydrochloride
Cat. No.：YN321347
| 产品名称: | Diphenidol hydrochloride |
| CAS No.: | 3254-89-5 |
| Chemical Name: | α,α-diphenyl-1-piperidinebutanol, monohydrochloride |
| Synonyms: | 盐酸地芬尼多; Difenidol hydrochloride |
| 分子量: | 345.91 |
| 分子式: | C₂₁H₂₈ClNO |
| SMILES: | OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Diphenidol hydrochloride (Difenidol hydrochloride) 是一种非选择性的毒蕈碱 M1-M4 受体 (muscarinic M1-M4receptor) 拮抗剂，具有抗心律失常活性。Diphenidol hydrochloride 也是神经细胞电压门控离子通道 (Na+，K+，Ca2+) 的有效非特异性阻滞剂。Diphenidol hydrochloride 是实验脊髓麻醉的潜在候选试剂。 |
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Varoli, L., Andreani, A., Burnelli, S., et al.Diphenidol-related diamines as novel muscarinic M4 receptor antagonistsBioorg. Med. Chem. Lett.18(9),2972-2976(2008)
Leung, Y.M., Wong, K.L., Cheng, K.S., et al.Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidolPharmacol. Rep.64(3),739-744(2012)
Kawabata, A., Sasa, M., Kishimoto, T., et al.Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotationJpn. J. Pharmacol.55(1),101-106(1991)
Nakayama, H., Yamakuni, H., Nakayama, A., et al.Diphenidol has no actual broad antiemetic activity in dogs and ferretsJ. Pharmacol. Sci.96(3),301-306(2004)
