Ipratropium bromide
Cat. No.：YN321435
| 产品名称: | Ipratropium bromide |
| CAS No.: | 22254-24-6 |
| Chemical Name: | (3-endo,8-syn)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane, monobromide |
| Synonyms: | 异丙托溴铵; Sch 1000 |
| 分子量: | 412.36 |
| 分子式: | C₂₀H₃₀BrNO₃ |
| SMILES: | C[N+]1([C@H]2CC[C@H]1CC(OC(C(CO)C3=CC=CC=C3)=O)C2)C(C)C.[Br-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ipratropium bromide (Sch 1000) 是毒蕈碱的受体 (muscarinic receptor) 的拮抗剂，对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9 nM、2 nM 和 1.7 nM。Ipratropium bromide 可用于 COPD 和 哮喘等研究。 |
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Prat, M., Buil, M.A., Fernández, M.D., et al.Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonistsBioorg. Med. Chem. Lett.25(8),1736-1741(2015)
Zhang, W., Fievez, L., Zhang, F., et al.Effects of formoterol and ipratropium bromide on repeated cadmium inhalation-induced pulmonary inflammation and emphysema in ratsEur. J. Pharmacol.647(1-3),178-187(2010)
