Trospium chloride
Cat. No.：YN321507
| 产品名称: | Trospium chloride |
| CAS No.: | 10405-02-4 |
| Chemical Name: | (1α,3β,5α)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium], monochloride |
| Synonyms: | 曲司氯铵 |
| 分子量: | 427.96 |
| 分子式: | C₂₅H₃₀ClNO₃ |
| SMILES: | [H][C@@]12CC[C@@](C[C@@H](OC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=O)C2)([H])[N+]15CCCC5.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Trospium chloride 是特异性、竞争性的毒蕈碱胆碱能受体 (mAChRs) 拮抗剂，具有抗毒蕈碱活性。Trospium chloride 能以高亲和力结合毒蕈碱受体 M1、M2 和 M3，但不与烟碱、胆碱能受体结合。 |
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Hegde, S.S.Muscarinic receptors in the bladder: From basic research to therapeuticsBr. J. Pharmacol.147(2),S80-S87(2006)
Maggiore, U.L.R., Salvatore, S., Alessandri, F., et al.Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in femalesExpert Opin. Drug Metab. Toxicol.8(11),1387-1408(2012)
Michel, M.C., and de la Rosette, J.J.M.C.H.Role of muscarinic receptor antagonists in urgency and nocturiaBJU Int.96(Suppl 1),37-42(2005)
