Benztropine mesylate
Cat. No.：YN321521
| 产品名称: | Benztropine mesylate |
| CAS No.: | 132-17-2 |
| Chemical Name: | (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, monomethanesulfonate |
| Synonyms: | 甲磺酸苯扎托品; Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate |
| 分子量: | 403.54 |
| 分子式: | C₂₂H₂₉NO₄S |
| SMILES: | CN1[C@H]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@@H]1CC2.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Benzatropine (Benzatropine) mesylate 是抗毒蕈碱的化合物，可辅助研究帕金森病。 |
| IC50和靶点: | |
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Zhang, Y., Joseph, D.B., Bowen, W.D., et al.Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analoguesJ. Med. Chem.44(23),3937-3945(2001)
Schmitt, K.C., Zhen, J., Kharkar, P., et al.Interaction of cocaine-, benztropine-, and GBR12909- like compounds with wildtype and mutant human dopamine transporters: Molecular features that differentially determine antagonist binding propertiesJ. Neurochem.107(4),928-940(2008)
Ukairo, O.T., Bondi, C.D., Newman, A.H., et al.Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residueJ. Pharmacol. Exp. Ther.314(2),575-583(2005)
Kornhuber, J., Muehlbacher, M., Trapp, S., et al.Identification of novel functional inhibitors of acid sphingomyelinasePLoS One6(8),1-13(2011)
