CFMTI
Cat. No.：YN320040
CAS No. ：864864-17-5
| 产品名称: | CFMTI |
| CAS No.: | 864864-17-5 |
| Chemical Name: | 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one |
| Synonyms: | 1H-Isoindol-1-one,2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-;CFMTI |
| 分子量: | 349.36 |
| 分子式: | C₁₉H₁₆FN₅O |
| SMILES: | O=C1N(C2CC2)CC3=C1C=CC(C4=C(C)N(C5=CC=CN=C5F)N=N4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CFMTI 作用于表达人和大鼠mGluR1a的 CHO 细胞，抑制L-谷氨酸诱导的细胞内 Ca2+，IC50分别为 2.6 和 2.3 nM。 |
| IC50和靶点: | [{name:"Human mGluR1a:2.6 nM (IC50)"},{name: "Rat mGluR1a:2.3 nM (IC50)"}] |
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Ito, S., Hirata, Y., Nagatomi, Y., et al.Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disordersBioorg. Med. Chem. Lett.19(18),5310-5313(2009)
Satow, A., Suzuki, G., Maehara, S., et al.Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-oneJ. Pharmacol. Exp. Ther.330(1),179-190(2009)
