(S)-MCPG
Cat. No.：YN320043
CAS No. ：150145-89-4
| 产品名称: | (S)-MCPG |
| CAS No.: | 150145-89-4 |
| Chemical Name: | (αS)-α-amino-4-carboxy-α-methyl-benzeneacetic acid |
| Synonyms: | (+)-MCPG |
| 分子量: | 209.20 |
| 分子式: | C₁₀H₁₁NO₄ |
| SMILES: | OC(C1=CC=C([C@](C)(N)C(O)=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。 |
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Jane, D.E., Jones, P.L., Pook, P.C., et al.Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neuronesNeuropharmacology32(7),725-727(1993)
Schoepp, D.D., Jane, D.E., and Monn, J.A.Pharmacological agents acting at subtypes of metabotropic glutamate receptorsNeuropharmacology38(10),1431-1476(1999)
Seal, A.J., Irving, A.J., Henley, J.M., et al.Stereoselective antagonism of the metabotropic glutamate receptor mCluRlα by α-met hyl-4-carboxyphenylglycineBiochem. Soc. Trans.22,138S(1994)
Huang, L., Rowan, M.J., and Anwyl, R.Induction of long-lasting depression by (+)-α-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitroEur. J. Pharmacol.366(2-3),151-158(1999)
Breakwell, N.A., Rowan, M.J., and Anwyl, R.(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptorJ. Neurophysiol.79(3),1270-1276(1998)
