VU0364770
Cat. No.：YN320056
CAS No. ：61350-00-3
| 产品名称: | VU0364770 |
| CAS No.: | 61350-00-3 |
| Chemical Name: | N-(3-chlorophenyl)-2-pyridinecarboxamide |
| Synonyms: | VU 0364770 |
| 分子量: | 232.67 |
| 分子式: | C₁₂H₉ClN₂O |
| SMILES: | O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0364770 是一种有效的选择性mGlu4正变构调节剂 (PAM)。VU0346770 对大鼠 mGlu4 和人 mGlu4 受体的EC50分别为 290 nM 和 1.1 μM。VU0364770 对 mGlu5 具有拮抗活性，EC50为 17.9 μM，VU0364770 对 mGlu6 具有正变构调节活性，EC50为 6.8 μM。VU0364770 还对 MAO 具有活性，作用于人 MAO-A 和 MAO-B 的 Ki值分别为8.5 和 0.72 μM。 |
| IC50和靶点: | [{name:"Rat mGlu4:290 nM (EC50)"},{name: "Human mGlu4:1.1 μM (EC50)"},{name: "mGlu6:6.8 μM (EC50)"},{name: "mGlu5:17.9 μM (EC50)"}] |
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Jones, C.K., Bubser, M., Thompson, A.D., et al.The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with ʟ-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's diseaseJ. Pharmacol. Exp. Ther.340(2),404-421(2012)
