CPPG
Cat. No.：YN320131
| 产品名称: | CPPG |
| CAS No.: | 183364-82-1 |
| Chemical Name: | α-amino-α-cyclopropyl-4-phosphono-benzeneacetic acid |
| Synonyms: | |
| 分子量: | 271.21 |
| 分子式: | C₁₁H₁₄NO₅P |
| SMILES: | O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPPG ((RS)-CPPG) 是一种有效的 II/III 型mGlu受体拮抗剂。CPPG 对大鼠大脑皮层中的 III 组 (IC50=2.2 nM) 比对 II 组（(IC50=46.2 nM) mGlu 受体有一定的选择性 (约 20 倍)。CPPG 对 I 组 mGlu 受体的作用较弱。 |
| IC50和靶点: | [{name:"group III mGlu receptors:2.2 nM (IC50)"},{name: "group II mGlu receptors:46.2 nM (IC50)"}] |
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Toms, N.J., Jane, D.E., Kemp, M.C., et al.The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonistBr. J. Pharmacol.119(5),851-854(1996)
Okubo, M., Yamanaka, H., Kobayashi, K., et al.Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviorsMol. Pain15,1-13(2019)
