DCG-IV
Cat. No.：YN320132
| 产品名称: | DCG-IV |
| CAS No.: | 147782-19-2 |
| Chemical Name: | (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine; (1R,2R)-3-[(S)-Aminocarboxymethyl]-1,2-cyclopropanedicarboxylic Acid |
| Synonyms: | |
| 分子量: | 203.15 |
| 分子式: | C₇H₉NO₆ |
| SMILES: | O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DCG-IV 是一种有效的 II 类mGluRs受体激动剂，对 mGlu2R 和 mGlu3R 的EC50值为 0.35 和 0.09 μM。DCG-IV 也是 I 组 (IC50: mGlu1R/5R=389/630 μM) 和 III 组受体 (IC50: mGlu4R/6R/7R/8R=22.5/39.6/40.1/32 μM) 的竞争性拮抗剂。DCG-IV 具有抗惊厥和神经保护作用。 |
| IC50和靶点: | [{name:"mGluR2R:0.35 μM (EC50)"},{name: "mGluR3R:0.09 μM (EC50)"},{name: "mGluR1R:389 μM (IC50)"},{name: "mGluR5:630 μM (IC50)"},{name: "mGluR4R:22.5 μM (IC50)"},{name: "mGluR6:39.6 μM (IC50)"},{name: "mGluR7:40.1 μM (IC50)"},{name: "mGluR8:32 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Bruno, V., et al.: J. Neurosci., 18, 9594 (1998)
Bruno, V., et al.: J. Neurosci., 17, 1891 (1997)
