CHPG
Cat. No.：YN320136
CAS No. ：170846-74-9
规格
价格(RMB)
库存
| 产品名称: | CHPG |
| CAS No.: | 170846-74-9 |
| Chemical Name: | α-amino-2-chloro-5-hydroxy-benzeneacetic acid |
| Synonyms: | |
| 分子量: | 201.61 |
| 分子式: | C₈H₈ClNO₃ |
| SMILES: | O=C(O)C(N)C1=CC(O)=CC=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHPG 是一个选择性的mGluR5激动剂，并且通过TSG-6/NF-κB途径减弱 BV2 小神经胶质细胞 SO2诱导的氧化应激和炎症。 CHPG 通过ERK和Akt途径在体外和体内预防创伤性脑损伤 (TBI)。 |
| IC50和靶点: | |
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Doherty, A.J., Palmer, M.J., Henley, J.M., et al.(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampusNeuropharmacology36(2),265-267(1997)
Mutel, V., Ellis, G.J., Adam, G., et al.Characterization of [3H]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sectionsJ. Neurochem.75(6),2590-2601(2000)
Qiu, J.-L., Zhu, W.-L., Lu, Y.-J., et al.The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cellsNeurochem Int.85-86,46-52(2015)
Loane, D.J., Stoica, B.A., Byrnes, K.R., et al.Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injuryJ. Neurotrauma30(5),403-412(2013)
