AMN082
Cat. No.：YN320267
CAS No. ：97075-46-2
| 产品名称: | AMN082 |
| CAS No.: | 97075-46-2 |
| Chemical Name: | N,N′-bis(diphenylmethyl)-1,2-ethanediamine, dihydrochloride |
| Synonyms: | AMN 082 dihydrochloride |
| 分子量: | 465.46 |
| 分子式: | C₂₈H₃₀Cl₂N₂ |
| SMILES: | [H]Cl.[H]Cl.C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMN082 是一种选择性，具有口服活性，可透过血脑屏障的mGluR7激动剂，通过跨膜区的变构位点直接激活受体信号。在表达 mGluR7 的转染哺乳动物细胞上，AMN082 有效抑制 cAMP 积累并刺激 GTPγS 结合 (EC50, 64-290 nM)。AMN082 对其他 mGluR 亚型和选择性离子型谷氨酸受体具有选择性。具有抗抑郁作用。 |
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Mitsukawa, K., Yamamoto, R., Ofner, S., et al.A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivoProc. Natl. Acad. Sci. USA102(51),18712-18717(2005)
Sukoff Rizzo, S.J., Leonard, S.K., Gilbert, A., et al.The metabotropic glutamate receptor 7 allosteric modulator AMN082: A monoaminergic agent in disguise?J. Pharmacol. Exp. Ther.338(1),345-352(2011)
Tian, Y., Liu, Y., Chen, X., et al.AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathwaysNeurochem. Int.57(1),8-15(2010)
Greco, B., Lopez, S., van der Putten, H., et al.Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's diseaseJ. Pharmacol. Exp. Ther.332(3),1064-1071(2010)
