(S)-3,5-DHPG
Cat. No.：YN320620
| 产品名称: | (S)-3,5-DHPG |
| CAS No.: | 162870-29-3 |
| Chemical Name: | (αS)-amino-3,5-dihydroxy-benzeneacetic acid |
| Synonyms: | |
| 分子量: | 183.16 |
| 分子式: | C₈H₉NO₄ |
| SMILES: | O=C(O)[C@@H](N)C1=CC(O)=CC(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-3,5-DHPG 是一种效力不高但具有选择性的 I 组代谢型谷氨酸受体 (mGluRs) 激动剂，对 mGluR1a 和 mGluR5a 的Ki值分别为 0.9 µM 和 3.9 µM。(S)-3,5-DHPG 在缺氧大鼠中表现出抗焦虑活性。 |
| IC50和靶点: | [{name:"mGluR1a:0.9 μM (Ki)"},{name: "mGluR5a:3.9 μM (Ki)"}] |
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Mutel, V., Ellis, G.J., Adam, G., et al.Characterization of [3H]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sectionsJ. Neurochem.75(6),2590-2601(2000)
Baker, S.R., Goldsworthy, J., Harden, R.C., et al.Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonistBioorg. Med. Chem. Lett.5(3),223-228(1995)
Clements, M.A., Swapna, I., and Morikawa, H.Inositol 1,4,5-triphosphate drives glutamatergic and cholinergic inhibition selectively in spiny projection neurons in the striatumJ. Neurosci.33(6),2697-2708(2013)
Grolla, A.A., Sim, J.A., Lim, D., et al.Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regionsCell Death Dis.,(2013)
