ADX-47273
Cat. No.：YN320684
CAS No. ：851881-60-2
| 产品名称: | ADX-47273 |
| CAS No.: | 851881-60-2 |
| Chemical Name: | (4-fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-methanone |
| Synonyms: | BA 94673139 |
| 分子量: | 369.36 |
| 分子式: | C₂₀H₁₇F₂N₃O₂ |
| SMILES: | O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ADX-47273 是一种有效的，选择性和可透过血脑屏障的mGluR5阳性变构调节剂 (PAM)，增强谷氨酸 (50 nM) 反应的EC50值为 0.17 μM。 ADX-47273 具有抗精神病和增强认知的活性。 |
| IC50和靶点: | [{name:"mGluR5:0.17 μM (EC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Liu, F., Grauer, S., Kelley, C., et al.ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activitiesJ. Pharmacol. Exp. Ther.327(3),827-839(2008)
Xu, J., Zhu, Y., Kraniotis, S., et al.Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learningLearn Mem.20(8),438-445(2013)
