MTEP hydrochloride
Cat. No.：YN320705
| 产品名称: | MTEP hydrochloride |
| CAS No.: | 1186195-60-7 |
| Chemical Name: | 3-[2-(2-methyl-4-thiazolyl)ethynyl]-pyridine, monohydrochloride |
| Synonyms: | 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐,3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride,MTEP |
| 分子量: | 236.72 |
| 分子式: | C₁₁H₉ClN₂S |
| SMILES: | CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MTEP hydrochloride 是非竞争性的mGlu5拮抗剂，IC50和Ki分别为 5 nM 和16 nM。MTEP hydrochloride 产生抗帕金森病样作用。 |
| IC50和靶点: | [{name:"mGluR5:5 nM (IC50)"},{name: "mGluR5:16 nM (Ki)"}] |
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Keck, T.M., Zou, M.F., Zhang, P., et al.Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigationACS Med. Chem. Lett.3(7),544-549(2012)
Pomierny-Chamiolo, L., Poleszak, E., Pilc, A., et al.NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in micePharmacol. Rep.62(6),1186-1190(2010)
Domin, H., Zieba, B., Golembiowska, K., et al.Neuroprotective potential of mGluR5 antagonist MTEP: Effects on kainate-induced excitotoxicity in the rat hippocampusPharmacol. Rep.62(6),1051-1061(2010)
Busse, C.S., Brodkin, J., Tattersall, D., et al.The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl] pyridine (MTEP) in rodent models of anxietyNeuropsychopharmacology29(11),1971-1979(2004)
