TCN238
Cat. No.：YN320866
CAS No. ：125404-04-8
| 产品名称: | TCN238 |
| CAS No.: | 125404-04-8 |
| Chemical Name: | (E)-4-(2-phenylethenyl)-2-pyrimidinamine |
| Synonyms: | TCN 238 |
| 分子量: | 197.24 |
| 分子式: | C₁₂H₁₁N₃ |
| SMILES: | NC1=NC=CC(/C=C/C2=CC=CC=C2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TCN238 是一种口服有效的mGlu4受体的正变构调节物，EC50值为 1 μM。 |
| IC50和靶点: | [{name:"mGlu4 Receptor:1 μM (EC50)"}] |
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| Solvent & Solubility: |
East, S.P., Bamford, S.J., Dietz, M.G.A., et al.An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunctionBioorg. Med. Chem. Lett.20(16),4901-4905(2010)
Pershina, E.V., and Arkhipov, V.I.Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brainLife Sci.153,50-54(2016)
