CDPPB
Cat. No.：YN320894
CAS No. ：781652-57-1
| 产品名称: | CDPPB |
| CAS No.: | 781652-57-1 |
| Chemical Name: | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamide |
| Synonyms: | CD-PPB |
| 分子量: | 364.40 |
| 分子式: | C₂₃H₁₆N₄O |
| SMILES: | O=C(NC1=CC(C2=CC=CC=C2)=NN1C3=CC=CC=C3)C4=CC=CC(C#N)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDPPB是一种有效，选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5)的正变构调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的EC50值为 27 nM。CDPPB 可能为抗精神病药的开发提供了一种方法。 |
| IC50和靶点: | [{name:"mGluR5:27 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lindsley, C.W., Wisnoski, D.D., Leister, W.H., et al.Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivoJ. Med. Chem.47(24),5825-5828(2004)
