Mavoglurant
Cat. No.：YN320952
CAS No. ：543906-09-8
| 产品名称: | Mavoglurant |
| CAS No.: | 543906-09-8 |
| Chemical Name: | (3aR,4S,7aR)-Octahydro-4-hydroxy-4-[(3-methylphenyl)ethynyl]-1H-indole-1-carboxylic Acid Methyl Ester; AFQ 056 |
| Synonyms: | AFQ056 |
| 分子量: | 313.39 |
| 分子式: | C₁₉H₂₃NO₃ |
| SMILES: | CC1=CC(C#C[C@]2(O)CCC[C@]3([H])[C@@]2([H])CCN3C(OC)=O)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mavoglurant (AFQ056) 是一种有效，选择性，非竞争性和口服活性的mGluR5拮抗剂，IC50值为 30 nM。Mavoglurant 对 mGluR5 显示出 >300 倍的选择性。Mavoglurant 可用于研究脆性 X 综合征 (FXS) 和帕金森氏症中左旋多巴引起的运动障碍。 |
| IC50和靶点: | [{name:"mGluR5:30 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Vranesic, I., et al.
Bioorg. Med. Chem., 22, 5790 (2014)
Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23, 6370 (2013)
