LY404039
Cat. No.：YN321288
CAS No. ：635318-11-5
| 产品名称: | LY404039 |
| CAS No.: | 635318-11-5 |
| Chemical Name: | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide |
| Synonyms: | pomaglumetad |
| 分子量: | 235.21 |
| 分子式: | C₇H₉NO₆S |
| SMILES: | O=C([C@]1(N)CS([C@@]2([H])[C@H](C(O)=O)[C@@]12[H])(=O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY404039 是一种有效的，选择性的，具有口服活性的mGluR2和mGluR3激动剂，对重组人mGluR2和mGluR3的Ki分别为 149 nM 和 92 nM，比对其他受体/转运蛋白的抑制性高 100 倍以上。LY404039 具有抗精神病和抗焦虑的作用。 |
| IC50和靶点: | [{name:"mGlu2 Receptor:149 nM (Ki, Recombinant human mGluR2)"},{name: "hmGluR3:92 nM (Ki)"}] |
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Rorick-Kehn, L.M., Johnson, B.G., Burkey, J.L., et al.Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)J. Pharmacol. Exp. Ther.321(1),308-317(2007)
Seeman, P., and Guan, H.C.Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptorSynapse63(10),935-939(2009)
Rorick-Kehn, L.M., Johnson, B.G., Knitowski, K.M., et al.In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disordersPsychopharmacology (Berl)193(1),121-136(2007)
