Cinnabarinic acid
Cat. No.：YN322104
| 产品名称: | Cinnabarinic acid |
| CAS No.: | 606-59-7 |
| Chemical Name: | 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid |
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| 分子量: | 300.22 |
| 分子式: | C₁₄H₈N₂O₆ |
| SMILES: | O=C(C1=C(N)C(C=C2OC3=C(N=C21)C(C(O)=O)=CC=C3)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cinnabarinic acid 是mGlu4特异性的别构激动剂，可以与 mGlu4 的谷氨酸结合袋残基相互作用，在其他 mGlu 受体亚型上没有活性。Cinnabarinic acid 是色氨酸 kynurenine 途径的内源性代谢物。Cinnabarinic acid 可以诱导细胞凋亡 (apoptosis)。 |
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Fazio, F., Lionetto, L., Molinaro, G., et al.Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptorsMol. Pharmacol.81(5),643-656(2012)
Subba Rao, P.V., and Vaidyanathan, C.S.Enzymic conversion of 3-hydroxyanthranilic acid into cinnabarinic acid. Partial purification and properties of rat-liver cinnabarinate synthaseBiochem. J.99(2),317-322(1966)
Lefin, R., Petzer, A., Cloete, S.J., et al.Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of ᴅ-amino acid oxidaseResults Chem.4,100278(2022)
Hiramatsu, R., Hara, T., Akimoto, H., et al.Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspaseJ. Cell. Biochem.103(1),42-53(2008)
