Zaldaride maleate
Cat. No.：YN360153
| 产品名称: | Zaldaride maleate |
| CAS No.: | 109826-27-9 |
| Chemical Name: | 1,3-dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one, 2Z-butenedioate |
| Synonyms: | CGS-9343B; KW 5617 |
| 分子量: | 544.60 |
| 分子式: | C₃₀H₃₂N₄O₆ |
| SMILES: | O=C(O)/C=C\C(O)=O.CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(N5C6=C(C=CC=C6)NC5=O)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zaldaride maleate (CGS-9343B) 是一个有效的、有口服活性的、选择性的钙调蛋白 (calmodulin) 的抑制剂，可抑制钙调蛋白刺激cAMP磷酸二酯酶的活性，IC50值为 3.3 nM。Zaldaride maleate (CGS-9343B) 可抑制雌激素诱导的 ER 转录激活，可逆地阻断 PC12 细胞中电压激活的的 Na+、Ca2+和 K+电流，抑制 nAChR。 |
| IC50和靶点: | |
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Norman, J.A., Ansell, J., Stone, G.A., et al.CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activityMol. Pharmacol.31(5),535-540(1987)
Hill, T.D., Campos-Gonzalez, R., Kindmark, H., et al.Inhibition of inositol trisphosphate-stimulated calcium mobilization by calmodulin antagonists in rat liver epithelial cellsJ. Biol. Chem.263(31),16479-16484(1988)
Shook, J.E., Burks, T.F., Wasley, J.W., et al.Novel calmodulin antagonist CGS 9343B inhibits secretory diarrheaJ. Pharmacol. Exp. Ther.251(1),247-252(1989)
