Asoxime dichloride
Cat. No.：YN360173
| 产品名称: | Asoxime dichloride |
| CAS No.: | 34433-31-3 |
| Chemical Name: | 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium, dichloride |
| Synonyms: | HI-6 |
| 分子量: | 359.21 |
| 分子式: | C₁₄H₁₆Cl₂N₄O₃ |
| SMILES: | O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asoxime dichloride 是乙酰胆碱受体 (AChRs) 拮抗剂，包括烟碱受体，α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用，改善神经系统的免疫效果。 |
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Wong, L., Radic, Z., Brüggermann, R.J.M., et al.Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesisBiochemistry39(19),5750-5757(2000)
RamaRao, G., Afley, P., Acharya, J., et al.Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changesBMC Neurosci.15,(2014)
Cochran, R., Kalisiak, J., Küçükkilinç, T., et al.Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist agingJ. Biol. Chem.286(34),29718-29724(2011)
