SIB-1553A
Cat. No.：YN360194
| 产品名称: | SIB-1553A |
| CAS No.: | 191611-89-9 |
| Chemical Name: | 4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]-phenol, monohydrochloride |
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| 分子量: | 273.82 |
| 分子式: | C₁₃H₂₀ClNOS |
| SMILES: | OC(C=C1)=CC=C1SCCC2N(CCC2)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SIB-1553A 是一种口服生物有效的烟碱乙酰胆碱受体(nAChRs)激动剂，对含有 nAChRs 的 β4 亚单位具有选择性。SIB-1553A 也是一种选择性配体神经元 nAChR 配体。SIB-1553A 是一种认知增强剂，对阿尔茨海默病和其他认知障碍的症状研究具有潜在的研究潜力。 |
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Bontempi, B., Whelan, K.T., Risbrough, V.B., et al.SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: Effects on working and reference memory performances in aged rodents and nonhuman primatesJ. Pharmacol. Exp. Ther.299(1),297-306(2001)
Schneider, J.S., Tinker, J.P., Menzaghi, F., et al.The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeysJ. Pharmacol. Exp. Ther.306(1),401-406(2003)
Terry, A.V., Jr., Risbrough, V.B., Buccafusco, J.J., et al.Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeysJ. Pharmacol. Exp. Ther.301(1),284-292(2002)
