A-867744
Cat. No.：YN360311
CAS No. ：1000279-69-5
| 产品名称: | A-867744 |
| CAS No.: | 1000279-69-5 |
| Chemical Name: | 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-benzenesulfonamide |
| Synonyms: | A 867744;A867744 |
| 分子量: | 402.89 |
| 分子式: | C₂₀H₁₉ClN₂O₃S |
| SMILES: | O=S(C1=CC=C(C=C1)N2C(C)=C(C=C2C3=CC=C(C=C3)Cl)C(CC)=O)(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-867744 是一种高效、选择性的 II 型alpha7 nAChR正变构调制剂 (PAM)，EC50值为 1.0 μM. |
| IC50和靶点: | |
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| Solvent & Solubility: |
Malysz, J., Grønlien, J.H., Anderson, D.J., et al.In vitro pharmacological characterization of a novel allosteric modulator of α7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profileJ. Pharmacol. Exp. Ther.330(1),257-267(2009)
Faghih, R., Gopalakrishnan, S.M., Gronlien, J.H., et al.Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptorJ. Med. Chem.52(10),3377-3384(2009)
