NS 1738
Cat. No.：YN360313
CAS No. ：501684-93-1
| 产品名称: | NS 1738 |
| CAS No.: | 501684-93-1 |
| Chemical Name: | N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-urea |
| Synonyms: | NSC 213859 |
| 分子量: | 365.13 |
| 分子式: | C₁₄H₉Cl₂F₃N₂O₂ |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)NC2=CC(Cl)=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NS 1738 (NSC 213859) 是一种新型的α7 nAChR正向变构调节剂。在卵母细胞实验中，正调节 α7nAChR，EC50为 3.4 μM。 |
| IC50和靶点: | |
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Timmermann, D.B., Gronlien, J.H., Kohlhaas, K.L., et al.An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivoJPET323(1),294-307(2007)
Cheng, Q., and Yakel, J.L.Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activationJ. Neurosci.34(1),124-133(2014)
Freitas, K., Carroll, F.I., and Damaj, M.I.The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain modelsJ. Pharmacol. Exp. Ther.344(1),264-275(2013)
