PNU-120596
Cat. No.：YN360314
CAS No. ：501925-31-1
| 产品名称: | PNU-120596 |
| CAS No.: | 501925-31-1 |
| Chemical Name: | N-(5-chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)-urea |
| Synonyms: | NSC 216666 |
| 分子量: | 311.72 |
| 分子式: | C₁₃H₁₄ClN₃O₄ |
| SMILES: | O=C(NC1=CC(Cl)=C(C=C1OC)OC)NC2=NOC(C)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PNU-120596 (NSC 216666) 是一种有效的选择性α7 nAChR阳性变构调节剂，EC50为 216 nM。PNU-120596 对 α4β2，α3β4 和 α9α10 nAChRs 无活性。PNU-120596 可用于精神病和神经疾病的研究。 |
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Hurst, R.S., Hajos, M., Raggenbass, M., et al.A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterizationJ. Neurosci.25(17),4396-4405(2015)
Timmermann, D.B., Gronlien, J.H., Kohlhaas, K.L., et al.An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivoJPET323(1),294-307(2007)
Kalappa, B.I., Sun, F., Johnson, S.R., et al.A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemiaBr. J. Pharmacol.169(8),1862-1878(2013)
