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Mecamylamine hydrochloride

Cat. No.:YN360863

  • CAS No. :826-39-1

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    • 参考文献
    • 产品名称: Mecamylamine hydrochloride
      CAS No.: 826-39-1
      Chemical Name: N,2,3,3-tetramethyl-bicyclo[2.2.1]heptan-2-amine, monohydrochloride
      Synonyms:盐酸美加明,Mevasin,Inversine
      分子量:203.75
      分子式:C₁₁H₂₂ClN
      SMILES:CC1(C)C(NC)(C)C2CCC1C2.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Mecamylamine hydrochloride 是一种具有口服活性,非选择性,非竞争性nAChR拮抗剂,具有抗神经疾病作用。Mecamylamine hydrochloride 是一种神经节阻滞剂,有潜力用于高血压研究。Mecamylamine hydrochloride 可以很容易地穿过血脑屏障。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Papke, R.L., Sanberg, P.R., and Shytle, R.D.Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypesJ. Pharmacol. Exp. Ther.297(2),646-656(2001)

      Damaj, M.I., Flood, P., Ho, K.K., et al.Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivityJ. Pharmacol. Exp. Ther.312(2),780-785(2005)

      Mineur, Y.S., and Picciotto, M.R.Nicotine receptors and depression: Revisiting and revising the chlorinergic hypothesisTrends Pharmacol. Sci.31(12),580-586(2010)

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