Cytisinicline
Cat. No.：YN360914
| 产品名称: | Cytisinicline |
| CAS No.: | 485-35-8 |
| Chemical Name: | (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Synonyms: | 金雀花碱; Cytisine; Sophorine; Baptitoxine |
| 分子量: | 190.24 |
| 分子式: | C₁₁H₁₄N₂O |
| SMILES: | O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytisinicline (Cytisine) 是一种生物碱，可在Laburnum和Cytisus等中提取得到。 Cytisinicline (Cytisine) 是 α4β2 烟碱乙酰胆碱能受体(α4β2 nAChRs)的部分激动剂，也是包含 β4 受体和 α7 受体的偏完全性激动剂。医学上已被用于帮助戒烟。 |
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Papke, R.L., and Heinemann, S.F.Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunitMol. Pharmacol.45(1),142-149(1994)
Xiao, Y., and Kellar, K.J.The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cellsJ. Pharmacol. Exp. Ther.310(1),98-107(2004)
Igari, M., Alexander, J.C., Ji, Y., et al.Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in ratsNeuropsychopharmacology39(2),455-465(2014)
