(±)-Anatoxin A fumarate
Cat. No.：YN360970
| 产品名称: | (±)-Anatoxin A fumarate |
| CAS No.: | 1219922-30-1 |
| Chemical Name: | 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-ethanone, 2-butenedioate |
| Synonyms: | |
| 分子量: | 281.30 |
| 分子式: | C₁₄H₁₉NO₅ |
| SMILES: | CC(C1=CCCC2CCC1N2)=O.O=C(O)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (±)-Anatoxin A fumarate 是从淡水蓝藻菌中分离得到的天然生物碱。(±)-Anatoxin A fumarate 是一种强效的烟碱受体 (nicotinic receptor) 激动剂，结合大鼠的脑膜的 α4β2 和 α7 型受体的Ki值分别为 1.25 nM 和 1.84 μM。(±)-Anatoxin A fumarate 刺激大鼠纹状体突触体释放多巴胺的EC50值为 134 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Aronstam, R.S., and Witkop, B.Anatoxin-a interactions with cholinergic synaptic moleculesProc. Natl. Acad. Sci. USA78(7),4639-4643(1981)
Sharples, C.G., Kaiser, S., Soliakov, L., et al.UB-165: A novel nicotinic agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomesJ. Neurosci.20(8),2783-2791(2000)
