Methyllycaconitine citrate
Cat. No.：YN360971
CAS No. ：351344-10-0
| 产品名称: | Methyllycaconitine citrate |
| CAS No.: | 351344-10-0 |
| Chemical Name: | 20-ethyl-1α,6β,14α,16β-tetramethoxy-4-[[[2-[(3S)-3-methyl-2,5-dioxo-1-pyrrolidinyl]benzoyl]oxy]methyl]-aconitane-7,8-diol, 2-hydroxy-1,2,3-propanetricarboxylate |
| Synonyms: | 甲基牛扁亭柠檬酸盐; MLA |
| 分子量: | 874.92 |
| 分子式: | C₄₃H₅₈N₂O₁₇ |
| SMILES: | CO[C@@H]1C(C(N(CC)C2)C3(O)[C@H]4OC)([C@@](C[C@@]5([H])[C@@H]6OC)([H])[C@@]6([H])[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]2(COC(C7=C(N(C8=O)C(C[C@@H]8C)=O)C=CC=C7)=O)CC1.O=C(CC(C(O)=O)(O)CC(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Methyllycaconitine citrate 是 α7 神经元烟碱型乙酰胆碱受体 (α7nAChR) 的特异性拮抗剂。 |
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Kalappa, B.I., Sun, F., Johnson, S.R., et al.A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemiaBr. J. Pharmacol.169(8),1862-1878(2013)
Ward, J.M., Cockcroft, V.B., Lunt, G.G., et al.Methyllycaconitine: A selective probe for neuronal α-bungarotoxin binding sitesFEBS Lett.270(1-2),45-48(1990)
Eaton, J.B., Peng, J.-H., Schroeder, K.M., et al.Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cellsMol. Pharmacol.64(6),1283-1294(2003)
Grinevich, V.P., Letchworth, S.R., Lindenberger, K.A., et al.Heterologous expression of human α6β4β3α5 nicotinic acetylcholine receptors: Binding properties consistent with their natural expression require quaternary subunit assembly including the α5 subunitJ. Pharm. Exp. Ther.312(2),619-626(2005)
Fan, B.-S., Zhang, E.-H., Wu, M., et al.Activation of α7 nicotinic acetylcholine receptor decreases on-site mortality in crush syndrome through insulin signaling-Na/K-ATPase pathwayFront. Pharmacol.7,79(2016)
Liu, L., Yu, J., Zhang, B., et al.Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotineSci. Rep.7,40467(2017)
