Myosmine
Cat. No.：YN361082
| 产品名称: | Myosmine |
| CAS No.: | 532-12-7 |
| Chemical Name: | 3-(3,4-dihydro-2H-pyrrol-5-yl)-pyridine |
| Synonyms: | 麦斯明 |
| 分子量: | 146.19 |
| 分子式: | C₉H₁₀N₂ |
| SMILES: | C1(C2=NCCC2)=CN=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Myosmine 是存在于坚果和坚果制品中的特定烟草生物碱，对 a4b2 烟碱乙酰胆碱受体 (nAChR) 具有低亲和力，Ki值为 3300 nM。 |
| IC50和靶点: | |
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Zaveri, N., Jiang, F., Olsen, C., et al.Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluationJ. Med. Chem.53(22),8187-8191(2010)
Tyroller, S., Zwickenpflung, W., and Richter, E.New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milkJ. Agric. Food Chem.50(17),4909-4915(2002)
Ferretti, G., Dukat, M., Giannella, M., et al.Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptorsBioorg. Med. Chem. Lett.13(4),733-735(2003)
Zwickenpflung, W., Tyroller, S., and Richter, E.Metabolism of myosmine in wistar ratsDrug Metab. Dispos.33(11),1648-1656(2005)
Hecht, S.S., Han, S., Kenney, P.M.J., et al.Investigation of the reaction of myosmine with sodium nitrite in vitro and in ratsChem. Res. Toxicol.20(3),543-549(2007)
