SB 203580
Cat. No.：YN350023
CAS No. ：152121-47-6
| 产品名称: | SB 203580 |
| CAS No.: | 152121-47-6 |
| Chemical Name: | 4-[4-(4-fluorophenyl)-2-[4-methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine |
| Synonyms: | RWJ 64809 |
| 分子量: | 377.43 |
| 分子式: | C₂₁H₁₆FN₃OS |
| SMILES: | O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 203580 (RWJ 64809) 是一种选择性的，ATP 竞争性的p38 MAPK抑制剂，对SAPK2a/p38和SAPK2b/p38β2的IC50分别为 50 nM 和 500 nM。SB 203580 抑制 LCK，GSK3β 和 PKBα，IC50比 SAPK2a/p38 高 100-500 倍。SB 203580 不抑制JNK活性，是一种自噬 (autophagy) 和线粒体自噬 (mitophagy) 激活剂。 |
| IC50和靶点: | [{name:"p38:50 nM (IC50)"},{name: "p38β2:500 nM (IC50)"}] |
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| Solvent & Solubility: |
Roux, P.P., and Blenis, J.ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functionsMicrobiol. Mol. Biol. Rev.68(2),320-344(2004)
Cuenda, A., Rouse, J., Doza, Y.N., et al.SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1FEBS Lett.364(2),229-233(1995)
Lali, F.V., Hunt, A.E., Turner, S.J., et al.The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity,protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinaseJ. Biol. Chem.275(10),7395-7402(2008)
