Talmapimod
Cat. No.：YN350040
CAS No. ：309913-83-5
| 产品名称: | Talmapimod |
| CAS No.: | 309913-83-5 |
| Chemical Name: | 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide |
| Synonyms: | 他匹莫德; SCIO-469 |
| 分子量: | 513.00 |
| 分子式: | C₂₇H₃₀ClFN₄O₃ |
| SMILES: | O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Talmapimod (SCIO-469) 是p38α选择性的，具有口服活性的，ATP 竞争性的抑制剂，IC50值是 9 nM，约为 p38β 的10倍，在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。 |
| IC50和靶点: | [{name:"p38α:9 nM (IC50)"},{name: "p38β:90 nM (IC50)"}] |
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| Solvent & Solubility: |
Hideshima, T., Podar, K., Chauhan, D., et al.p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cellsOncogene23(54),8766-8776(2004)
Vanderkerken, K., Medicherla, S., Coulton, L., et al.Inhibition of p38α mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myelomaCancer Res.67(10),4572-4577(2007)
