TAK-715
Cat. No.：YN350041
CAS No. ：303162-79-0
| 产品名称: | TAK-715 |
| CAS No.: | 303162-79-0 |
| Chemical Name: | N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-benzamide |
| Synonyms: | TAK-715; TAK715 |
| 分子量: | 399.51 |
| 分子式: | C₂₄H₂₁N₃OS |
| SMILES: | O=C(C1=CC=CC=C1)NC2=NC=CC(C3=C(N=C(S3)CC)C4=CC=CC(C)=C4)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAK-715 是一种具有口服活性，有效的p38 MAPK抑制剂，对 p38α 和 p38β 的IC50分别为 7.1 nM，200 nM。TAK-715 抑制酪蛋白激酶 I (CK1δ/ε)，从而调节 Wnt/β-catenin 信号传导的激活。TAK-715 在大鼠关节炎模型中显示出良好的作用。 |
| IC50和靶点: | [{name:"p38α:7.1 nM (IC50)"},{name: "p38β:200 nM (IC50)"},{name: "p38δ:>10 μM (IC50)"},{name: "p38γ:>10 μM (IC50)'}, 'CK1δ', 'CK1ε'] |
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Miwatashi, S., Arikawa, Y., Kotani, E., et al.Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agentJ. Med. Chem.48(19),5966-5979(2005)
Verkaar, F., van der Stelt, M., Blankesteijn, W.M., et al.Discovery of novel small molecule activators of β-catenin signalingPLoS One6(4),e19185(2011)
