PD 169316
Cat. No.：YN350046
CAS No. ：152121-53-4
| 产品名称: | PD 169316 |
| CAS No.: | 152121-53-4 |
| Chemical Name: | 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]-pyridine |
| Synonyms: | PD 169316,PD-169316 |
| 分子量: | 360.34 |
| 分子式: | C₂₀H₁₃FN₄O₂ |
| SMILES: | FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)NC(C4=CC=C([N+]([O-])=O)C=C4)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 169316 是一种高效，细胞透过的，有选择性的p38 MAP kinase抑制剂，IC50值为 89 nM。PD169316 选择性地抑制磷酸化 p38 的激酶活性，但不阻碍上游激酶磷酸化 p38。PD169316 显示对 Enterovirus71 有抗病毒活性。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Gallagher, T.F., Seibel, G.L., Kassis, S., et al.Regulation of stress-induced cytokine production by pyridinylimidazoles; Inhibition of CSBP kinaseBioorg. Med. Chem.5(1),49-64(1997)
Nath, R., McGinnis, K., Dutta, S., et al.Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neuronsCell. Mol. Biol. Lett.6,173-184(2001)
Kummer, J.L., Rao, P.K., and Heidenreich, K.A.Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinaseJ. Biol. Chem.272(33),20490-20494(1997)
