SB 239063
Cat. No.：YN350068
CAS No. ：193551-21-2
| 产品名称: | SB 239063 |
| CAS No.: | 193551-21-2 |
| Chemical Name: | trans-4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-cyclohexanol |
| Synonyms: | SB239063 |
| 分子量: | 368.40 |
| 分子式: | C₂₀H₂₁FN₄O₂ |
| SMILES: | COC1=NC=CC(C2=C(N=CN2[C@H]3CC[C@H](O)CC3)C4=CC=C(F)C=C4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB 239063 是一种有效、选择性、可口服的p38 MAPK抑制剂，对重组纯化的人 p38α 的IC50值为 44 nM，对 p38α 和 p38β 的活性等效，但对 p38γ 或 p38δ 无所用。具有抗哮喘作用，还被用于增强因衰老或疾病受损的记忆，如阿尔茨海默病。 |
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Underwood, D.C., Osborn, R.R., Kotzer, C.J., et al.SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistenceJ. Pharmacol. Exp. Ther.293(1),281-288(2000)
Barone, F.C., Irving, E.A., Ray, A.M., et al.SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemiaJ. Pharmacol. Exp. Ther.296(2),312-321(2001)
