R1487 Hydrochloride
Cat. No.：YN350152
CAS No. ：449808-64-4
| 产品名称: | R1487 Hydrochloride |
| CAS No.: | 449808-64-4 |
| Chemical Name: | 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one, monohydrochloride |
| Synonyms: | R1487 (Hydrochloride) |
| 分子量: | 424.83 |
| 分子式: | C₁₉H₁₉ClF₂N₄O₃ |
| SMILES: | O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R1487 Hydrochloride 是强效、选择性的p38α抑制剂，其对 p38α 和 p38β 的Kd值分别为 0.2 nM 和 29 nM。 |
| IC50和靶点: | [{name:"p38α:0.2 nM (Kd)"},{name: "p38β:29 nM (Kd)"}] |
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| Solvent & Solubility: |
Goldstein, D.M., Soth, M., Gabriel, T., et al.Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinaseJ. Med. Chem.54(7),2255-2265(2011)
