SB 242235
Cat. No.：YN350184
CAS No. ：193746-75-7
| 产品名称: | SB 242235 |
| CAS No.: | 193746-75-7 |
| Chemical Name: | 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-pyrimidine |
| Synonyms: | SB-242235,SB242235 |
| 分子量: | 353.39 |
| 分子式: | C₁₉H₂₀FN₅O |
| SMILES: | COC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB-242235 是一种有效、选择性的p38 MAP激酶抑制剂，在人的软骨细胞中IC50值为 1.0 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Adams, J.L., Boehm, J.C., Gallagher, T.F., et al.Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activityBioorg. Med. Chem. Lett.11(21),2867-2870(2001)
Badger, A.M., Roshak, A.K., Cook, M.N., et al.Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte culturesOsteoarthritis Cartilage8(6),434-443(2000)
Kim, A.L., Labasi, J.M., Zhu, Y., et al.Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless miceJ. Invest. Dermatol.124(6),1318-1325(2005)
Badger, A.M., Griswold, D.E., Kapadia, R., et al.Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritisArthritis Rheum.43(1),175-183(2000)
