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Cornuside

Cat. No.:YN350230

  • CAS No. :131189-57-6

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    • 生物活性
    • 参考文献
    • 产品名称: Cornuside
      CAS No.: 131189-57-6
      Chemical Name: 3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-2H-pyran-5-carboxylic acid, methyl ester
      Synonyms:山茱萸新苷
      分子量:542.49
      分子式:C₂₄H₃₀O₁₄
      SMILES:O=C(C1=CC(O)=C(O)C(O)=C1)OCCC(C(C(OC)=O)=COC2OC(C(C(O)C3O)O)OC3CO)C2C=C
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Cornuside 是一种从山茱萸 (Cornus officinalisSieb. et Zucc.) 的果实中分离出的环烯醚萜苷,山茱萸是一种传统的东方医药,可用于炎症疾病的研究和促进血液循环。 Cornuside 通过下调MAPK和NF-κB信号通路抑制肥大细胞介导的过敏反应。Cornuside 的体内和体外抗过敏作用表明该药物有用于炎性过敏性疾病中的潜能。
      IC50和靶点:
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    • Gao, F., Xia, S.-L., Wang, X.-H., et al.Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathwayJ. Orthop. Surg. Res.16(1),397(2021)

      Zhang, R., Liu, J., Xu, B., et al.Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous systemJ. Zhejiang Univ. Sci. B22(5),421-430(2021)

      Kim, N., Kim, C., Ryu, S.H., et al.Anti-septic functions of cornuside against HMGB1-mediated severe inflammatory responsesInt. J. Mol. Sci.23(4),2065(2022)

      Liu, L., Shu, A., Zhu, Y., et al.Cornuside alleviates diabetes mellitus-induced testicular damage by modulating the gut microbiotaEvid. Based Complement. Alternat. Med.,5301942(2021)

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