CB-5083
Cat. No.：YN290222
CAS No. ：1542705-92-9
| 产品名称: | CB-5083 |
| CAS No.: | 1542705-92-9 |
| Chemical Name: | 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide |
| Synonyms: | CB 5083,CB5083 |
| 分子量: | 413.47 |
| 分子式: | C₂₄H₂₃N₅O₂ |
| SMILES: | O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CB-5083是有效，选择性和有口服活性的p97抑制剂，IC50值为 11 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Anderson, D.J., Le Moigne, R., Dkjakovic, S., et al.Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein HomeostasisCancer Cell.28(5),653-665(2015)
Zhou, H.-J., Wang, J., Yao, B., et al.Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083)J. Med. Chem.58(24),9480-9497(2015)
