NMS-873
Cat. No.：YN290364
CAS No. ：1418013-75-8
| 产品名称: | NMS-873 |
| CAS No.: | 1418013-75-8 |
| Chemical Name: | 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-pyridine |
| Synonyms: | NMS873; NMS 873 |
| 分子量: | 520.67 |
| 分子式: | C₂₇H₂₈N₄O₃S₂ |
| SMILES: | CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NMS-873 是一种有效，选择性的VCP/p97变构抑制剂，IC50值为 30 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chou, T.F., and Deshaies, R.J.Development of p97 AAA ATPase inhibitorsAutophagy7(9),1091-1092(2011)
Polucci, P., Magnaghi, P., Angiolini, M., et al.Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationshipsJ. Med. Chem.56(2),437-450(2013)
