TMPyP4 tosylate
Cat. No.：YN290085
| 产品名称: | TMPyP4 tosylate |
| CAS No.: | 36951-72-1 |
| Chemical Name: | 4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[1-methyl-pyridinium], 4-methylbenzenesulfonate (1:4) |
| Synonyms: | TMP 1363 |
| 分子量: | 1363.60 |
| 分子式: | C₇₂H₆₆N₈O₁₂S₄ |
| SMILES: | C[N+]1=CC=C(/C2=C3C=CC(/C(C4=CC=[N+](C)C=C4)=C5C=C/C(N/5)=C(C6=CC=[N+](C)C=C6)/C(C=C/7)=NC7=C(C8=CC=[N+](C)C=C8)/C9=CC=C2N9)=N\3)C=C1.O=S(C%10=CC=C(C)C=C%10)([O-])=O.O=S(C%11=CC=C(C)C=C%11)([O-])=O.O=S(C%12=CC=C(C)C=C%12)([O-])=O.O=S(C%13=CC=C(C)C=C%13)([ |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体，可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂，在骨肉瘤细胞系中具有抗肿瘤作用。 |
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Fiel, R.J., Howard, J.C., Mark, E.H., et al.Interaction of DNA with a porphyrin ligand: Evidence for intercalationNucleic Acids Res.6(9),3093-3118(1979)
Izbicka, E., Wheelhouse, R.T., Raymond, E., et al.Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cellsCancer Res.59,639-644(1999)
Rapozzi, V., Zorzet, S., Zacchigna, M., et al.Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studiesMol. Cancer13,75(2014)
Rha, S.Y., Izbicka, E., Lawrence, R., et al.Effect of telomere and telomerase interactive agents on human tumor and normal cell linesClin. Cancer Res.6,987-993(2000)
Fujiwara, N., Mazzola, M., Cai, E., et al.TMPyP4, a stabilizer of nucleic acid secondary structure, is a novel acetylcholinesterase inhibitorPLoS One10(9),e0139167(2015)
