Pyridostatin TFA
Cat. No.：YN290335
| 产品名称: | Pyridostatin TFA |
| CAS No.: | 1472611-44-1 |
| Chemical Name: | 4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide, trifluoroacetate salt |
| Synonyms: | RR82 TFA |
| 分子量: | 710.66 |
| 分子式: | C₃₃H₃₃F₃N₈O₇ |
| SMILES: | O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pyridostatin (RR82) TFA 是一种高选择性的G-quadruplex DNA稳定剂 (Kd=490 nM)。Pyridostatin TFA 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin TFA 靶向原癌基因 Src。Pyridostatin TFA 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。 |
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Rodriguez, R., Miller, K.M., Forment, J.V., et al.Small-molecule-induced DNA damage identifies alternative DNA structures in human genesNat. Chem. Biol.8(3),301-310(2012)
