E 2012
Cat. No.：YN380003
CAS No. ：870843-42-8
| 产品名称: | E 2012 |
| CAS No.: | 870843-42-8 |
| Chemical Name: | (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidinone |
| Synonyms: | (E)-1-[(1S)-1-(4-氟苯基)乙基]-3-[3-甲氧基-4-(4-甲基-1H-咪唑-1-YL)亚苄基]哌啶-2-酮 |
| 分子量: | 419.49 |
| 分子式: | C₂₅H₂₆FN₃O₂ |
| SMILES: | O=C(N([C@H](C1=CC=C(C=C1)F)C)CCC/2)C2=C\C3=CC=C(N4C=NC(C)=C4)C(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | E 2012 是有效的γ 分泌酶调节剂，不会影响 Notch 加工。E 2012 在胆固醇生物合成的最后一步抑制 3β-羟基固醇 Δ24-还原酶(DHCR24)。E 2012 旨在通过减少淀粉样蛋白 β-42 减少阿兹海默氏病，并在大鼠多次重复给药后诱发白内障。 |
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Dimitrov, M., Alattia, J.-R., Lemmin, T., et al.Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD productionNat. Commun.4:2246,(2013)
Nakano-Ito, K., Fujikawa, Y., Hihara, T., et al.E2012-induced cataract and its predictive biomarkersToxicol. Sci.137(1),249-258(2014)
Kimura, T., Kawano, K., Doi, E., et al.Cinnamide compound,(2005)
