NGP555
Cat. No.：YN380033
CAS No. ：1304630-27-0
| 产品名称: | NGP555 |
| CAS No.: | 1304630-27-0 |
| Chemical Name: | N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolamine |
| Synonyms: | |
| 分子量: | 406.52 |
| 分子式: | C₂₃H₂₃FN₄S |
| SMILES: | CC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NGP555 是一个 γ-分泌酶 (γ-secretase) 调节剂。 |
| IC50和靶点: | |
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Kounnas, M.Z., Danks, A.M., Cheng, S., et al.Modulation of γ-secretase reduces β-amyloid deposition in a transgenic mouse model of Alzheimer's diseaseNeuron67(5),769-780(2010)
Kounnas, M.Z., Lane-Donovan, C., Nowakowski, D.W., et al.NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodentsAlzheimers Dement. TRCI3(1),65-73(2017)
