MRK-560
Cat. No.：YN380087
CAS No. ：677772-84-8
| 产品名称: | MRK-560 |
| CAS No.: | 677772-84-8 |
| Chemical Name: | N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide |
| Synonyms: | MRK560 |
| 分子量: | 517.92 |
| 分子式: | C₁₉H₁₇ClF₅NO₄S₂ |
| SMILES: | O=S([C@]1(C2=C(C=CC(F)=C2)F)CC[C@H](NS(C(F)(F)F)(=O)=O)CC1)(C3=CC=C(Cl)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRK-560 是一种高效、有口服生物活性，可渗透大脑屏障的 γ- 分泌酶抑制剂(γ-secretase)抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Churcher, I., Beher, D., Best, J.D., et al.4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitorsBioorg. Med. Chem. Lett.16(2),280-284(2006)
Best, J.D., Jay, M.T., Otu, F., et al.In vivo characterization of Aβ(40) changes in brain and cerebrospinal fluid using the novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the ratJ. Pharmacol. Exp. Ther.317(2),786-790(2006)
Townsend, M., Qu, Y., Gray, A., et al.Oral treatment with a γ-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's diseaseJ. Pharmacol. Exp. Ther.333(1),110-119(2010)
