Begacestat
Cat. No.：YN380088
CAS No. ：769169-27-9
| 产品名称: | Begacestat |
| CAS No.: | 769169-27-9 |
| Chemical Name: | 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide |
| Synonyms: | GSI-953 |
| 分子量: | 391.74 |
| 分子式: | C₉H₈ClF₆NO₃S₂ |
| SMILES: | FC(F)(F)C([C@H](NS(=O)(C1=CC=C(Cl)S1)=O)CO)C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Begacestat (GSI-953) 是淀粉样前体蛋白 γ 分泌酶 (gamma-secretase) 的选择性噻吩磺酰胺抑制剂 (IC50Aβ40=15 nM)，有潜力用于阿尔兹海默症的研究。 |
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Mayer, S.C., Kreft, A.F., Harrison, B., et al.Discovery of begacestat, a Notch-1-sparing γ-secretase inhibitor for the treatment of Alzheimer's diseaseJ. Med. Chem.51(23),7348-7351(2008)
Martone, R.L., Zhou, H., Atchison, K., et al.Begacestat (GSI-953): A novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's diseaseJ. Pharmacol. Exp. Ther.331(2),598-608(2009)
