Compound E
Cat. No.：YN380089
| 产品名称: | Compound E |
| CAS No.: | 209986-17-4 |
| Chemical Name: | N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide |
| Synonyms: | |
| 分子量: | 490.50 |
| 分子式: | C₂₇H₂₄F₂N₄O₃ |
| SMILES: | FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Compound E 是γ-secretase抑制剂。 Compound E 抑制 β-amyloid(40)，β-amyloid(42)，和Notch γ-分泌酶切割的IC50值分别为 0.24，0.37，0.32 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Zhao, G., Mao, G., Tan, J., et al.Identification of a new presenilin-dependent ζ-cleavage site within the transmembrane domain of amyloid precursor proteinJ. Biol. Chem.279(49),50647-50650(2004)
Ferrari-Toninelli, G., Bonini, S.A., Uberti, D., et al.Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cellsNeuro. Oncol.12(12),1231-1243(2010)
Jovanovic, V.P., Sauer, C.M., Shawber, C.J., et al.Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)Reprod. Biol. Endocrinol.11,43(2013)
Doerfler, P., Shearman, M.S., and Perlmutter, R.M.Presenilin-dependent γ-secretase activity modulates thymocyte developmentProc. Natl. Acad. Sci. USA98(16),9312-9317(2001)
