Itanapraced
Cat. No.：YN380099
CAS No. ：749269-83-8
| 产品名称: | Itanapraced |
| CAS No.: | 749269-83-8 |
| Chemical Name: | 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid |
| Synonyms: | CHF5074; CSP-1103 |
| 分子量: | 325.16 |
| 分子式: | C₁₆H₁₁Cl₂FO₂ |
| SMILES: | OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Itanapraced (CHF5074) 是一种新型γ-secretase调节剂, 降低 Aβ42 和Aβ40 分泌, IC50分别为3.6和18.4 μM。 |
| IC50和靶点: | |
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Peretto, I., Radaelli, S., Parini, C., et al.Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of β-amyloid1-42 secretionJ. Med. Chem.48(18),5705-5720(2005)
Imbimbo, B.P., Del Giudice, E., Colavito, D., et al.1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel γ-secretase modulator, reduces brain β-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicityJ. Pharmacol. Exp. Ther.323(3),822-830(2007)
Imbimbo, B.P., Hutter-Paier, B., Villetti, G., et al.CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's diseaseBr. J. Pharmac.156(6),982-993(2009)
