Nirogacestat
Cat. No.：YN380106
CAS No. ：1290543-63-3
| 产品名称: | Nirogacestat |
| CAS No.: | 1290543-63-3 |
| Chemical Name: | (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide |
| Synonyms: | PF-3084014; PF-03084014 |
| 分子量: | 489.64 |
| 分子式: | C₂₇H₄₁F₂N₅O |
| SMILES: | FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nirogacestat (PF-3084014) 是一种有效的，具有口服活性的，可逆的非竞争性的选择性的γ-secretase抑制剂，IC50为 6.2 nM。Nirogacestat 抑制 Notch 信号通路，同时最小化胃肠道毒性。可用于研究 Notch 受体依赖性肿瘤。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lanz, T.A., Wood, K.M., Richter, K.E.G., et al.Pharmacodynamics and pharmacokinetics of the γ-secretase inhibitor PF-3084014J. Pharmacol. Exp. Ther.334(1),269-277(2010)
